Configure Wake-on-LAN using systemd.

Inspect interfaces.

$ ip address

1: lo: <LOOPBACK,UP,LOWER_UP> mtu 65536 qdisc noqueue state UNKNOWN group default qlen 1000
    link/loopback 00:00:00:00:00:00 brd 00:00:00:00:00:00
    inet 127.0.0.1/8 scope host lo
       valid_lft forever preferred_lft forever
    inet6 ::1/128 scope host 
       valid_lft forever preferred_lft forever
2: enp2s0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc pfifo_fast master vmbr0 state UP group default qlen 1000
    link/ether b4:b0:24:2c:9f:30 brd ff:ff:ff:ff:ff:ff
3: vmbr0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc noqueue state UP group default qlen 1000
    link/ether b4:b0:24:2c:9f:30 brd ff:ff:ff:ff:ff:ff
    inet 172.16.150.202/21 scope global vmbr0
       valid_lft forever preferred_lft forever
    inet6 fe80::b6b0:24ff:fe2c:9f30/64 scope link 
       valid_lft forever preferred_lft forever

Inspect interface details.

$ sudo ethtool enp2s0

Settings for enp2s0:
        Supported ports: [ TP    MII ]
        Supported link modes:   10baseT/Half 10baseT/Full
                                100baseT/Half 100baseT/Full
                                1000baseT/Full
        Supported pause frame use: Symmetric Receive-only
        Supports auto-negotiation: Yes
        Supported FEC modes: Not reported
        Advertised link modes:  10baseT/Half 10baseT/Full
                                100baseT/Half 100baseT/Full
                                1000baseT/Full
        Advertised pause frame use: Symmetric Receive-only
        Advertised auto-negotiation: Yes
        Advertised FEC modes: Not reported
        Link partner advertised link modes:  10baseT/Half 10baseT/Full
                                             100baseT/Half 100baseT/Full
                                             1000baseT/Full
        Link partner advertised pause frame use: Symmetric
        Link partner advertised auto-negotiation: Yes
        Link partner advertised FEC modes: Not reported
        Speed: 1000Mb/s
        Duplex: Full
        Auto-negotiation: on
        master-slave cfg: preferred slave
        master-slave status: slave
        Port: Twisted Pair
        PHYAD: 0
        Transceiver: external
        MDI-X: Unknown
        Supports Wake-on: pumbg
        Wake-on: d
        Link detected: yes

Configure Wake-on-LAN on enp2s0 interface to activate using magic packet.

$ sudo ethtool --change enp2s0 wol g

Inspect interface details.

$ ethtool enp2s0

Settings for enp2s0:
        Supported ports: [ TP    MII ]
        Supported link modes:   10baseT/Half 10baseT/Full
                                100baseT/Half 100baseT/Full
                                1000baseT/Full
        Supported pause frame use: Symmetric Receive-only
        Supports auto-negotiation: Yes
        Supported FEC modes: Not reported
        Advertised link modes:  10baseT/Half 10baseT/Full
                                100baseT/Half 100baseT/Full
                                1000baseT/Full
        Advertised pause frame use: Symmetric Receive-only
        Advertised auto-negotiation: Yes
        Advertised FEC modes: Not reported
        Link partner advertised link modes:  10baseT/Half 10baseT/Full
                                             100baseT/Half 100baseT/Full
                                             1000baseT/Full
        Link partner advertised pause frame use: Symmetric
        Link partner advertised auto-negotiation: Yes
        Link partner advertised FEC modes: Not reported
        Speed: 1000Mb/s
        Duplex: Full
        Auto-negotiation: on
        master-slave cfg: preferred slave
        master-slave status: slave
        Port: Twisted Pair
        PHYAD: 0
        Transceiver: external
        MDI-X: Unknown
        Supports Wake-on: pumbg
        Wake-on: g
        Link detected: yes

Unfortunately, this is not persistent and Wake-on-LAN will be disabled next time you start the machine.

$ sudo tee /etc/systemd/network/10-enp2s0.link << EOF
[Match]
MACAddress=b4:b0:24:2c:9f:30

[Link]
WakeOnLan=magic
EOF

[Match]
MACAddress=b4:b0:24:2c:9f:30

[Link]
WakeOnLan=magic

Simple as that. Inspect systemd.link manual page for more details.