How to boot ISO file directly from USB drive

Use Ventoy an open source tool to create bootable USB drive for ISO/IMG/VHD/… files.

Open Ventoy GitHub releases page and download release for your operating system.

I will download ventoy-1.0.62-linux.tar.gz, but you can also use ventoy-1.0.62-livecd.iso to create Ventoy USB drive using livecd GUI.

Extract downloaded release for linux.

$ tar xvfz ventoy-1.0.62-linux.tar.gz

Start GUI application and create USB device. Alternatively, you can use CLI or WEB utility.

$ sudo ./VentoyGUI.x86_64

Connect USB device again to refresh its state and copy ISO images.

Alter default settings. Inspect Ventoy documentation for more details.

$ sudo ./VentoyPlugson.sh /dev/sdx

Ventoy version in Disk: 1.0.62
Disk Partition Style  : MBR
Secure Boot Support   : NO
/dev/sdg1 is mounted at /media/milosz/Ventoy exfat
create ventoy directory

===============================================================
  Ventoy Plugson Server is running ...
  Please open your browser and visit http://127.0.0.1:24681
===============================================================

################## Press Ctrl + C to exit #####################

[...]

Boot the livecd.

The best part is that it works flawlessly!